4th March 2024

A 9-month-old male is known to have hypertonia and seizure episodes

A 9-month-old male is known to have hypertonia and seizure episodes. His mother noted that her pregnancy was complicated with intrauterine growth restriction and polyhydramnios. USS during pregnancy also revealed an omphalocele along with a ventricular septal defect. He had poor psychomotor development and failed to achieve most developmental milestones. On examination today, he has micrognathia, microcephaly, prominent occiput microphthalmia with increased space between his eyes and short palpebral fissures. He has a short sternum with bilateral clenched hands and overriding fingers. His feet have prominent calcaneus with convex-appearing feet bilaterally.

Which of the following aneuploidy likely resulted in the above clinical condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.