20th February 2024

A couple has attended the fertility clinic after experiencing four miscarriages

A couple has attended the fertility clinic after experiencing four miscarriages in the past six months. Sperm analysis on the male partner had not shown any apparent abnormalities, and genetic analysis of the foetal tissue using aCGH suggests excess genetic material from chromosome 4. Karyotyping of the foetal DNA has shown 46 XX with excess material seen on chromosome 20.

Given the foetal genetic analysis, which phase in the cell cycle during meiosis has resulted in the predicted abnormality within the parental DNA?

Select the SINGLE most appropriate option from the list below. Select ONE option only.