21st July 2023

A medical student approaches you as he has a keen interest in pathology and has seen a patient on the ward who has a diagnosis of progressive supranuclear palsy.

A medical student approaches you as he has a keen interest in pathology and has seen a patient on the ward who has a diagnosis of progressive supranuclear palsy. He has examined him and has discovered an abnormality in his cranial nerves, an unsteady gait and feels the patient may have some cognitive deficit. He asks what is the pathophysiology behind progressive supranuclear palsy.

The accumulation of which type of protein is implicated in progressive supranuclear palsy?

Select the SINGLE most appropriate option from the list below. Select ONE option only.