4th March 2024

The respiratory clinic follows up on a 24-year-old male for his long-term condition

The respiratory clinic follows up on a 24-year-old male for his long-term condition. Since birth, he had struggled to gain weight despite having a healthy appetite. He struggled with recurrent sinusitis and frequently had chest infections during his childhood. He also recalled having issues with loose stools that would not flush down the toilet. This settled once he commenced on Creon. Examination today revealed a hyperinflated chest with coarse crepitations. He also has finger clubbing on all of his fingers.

Which of the following genes is implicated in this condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.