5th June 2025

Complications

Joint destruction causing work disability and requiring joint replacement surgeries
Shortened life span – 8-10 years on average
Increased risk for coronary artery disease
Interstitial lung disease (ILD)
Felty syndrome – defines as the presence of RA, splenomegaly, and an abnormally low white blood cell count; seen in less than 1% of patients
Carpal tunnel syndrome – seen in 10-20%
Secondary to immunosuppressive effects of treatment – infection, malignancy, methotrexate-related liver toxicity

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