30th July 2026

Background

Steven-Johnson’s Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are severe skin reactions affecting both cutaneous and mucosal tissue. The two conditions are a continuum of the same disease process differentiated by the total body surface area (TBSA) affected. Although rare, SJS/TEN are associated with a high mortality rate, 10% and 30% respectively. The main causative factor is medication however infection and malignancy can also trigger the reaction.