Gestational hypertension
Background
Gestational hypertension (GH) is hypertension (blood pressure > 140/90 mmHg on two occasions measured at least 4 hours apart) that develops after 20 weeks’ gestation in previously normotensive women in the absence of proteinuria. GH is a common complication in pregnancy and affects 6-10% of pregnancies globally.
Risk factors
- Age > 40 years
- Pre-existing hypertension, including essential hypertension, preeclampsia or gestational hypertension
- Pre-existing renal or vascular disease
- Obesity
- Diabetes
- Nulliparous
- Multiple pregnancy
- Pregnancy interval > 10 years
- Family history of preeclampsia
- Black or Hispanic ethnicity
Clinical features
- Most women are asymptomatic
- Headache that is persistent and severe
- Visual disturbances
- Women should be asked about symptoms that suggest pre-eclampsia, e.g. weight gain, peripheral oedema, headaches, and upper abdominal pain
Diagnosis and investigations
Table 6. Investigations for gestational hypertension
| Investigation | Notes |
|---|---|
| Blood pressure measurement |
|
| Urine protein |
|
| FBC |
|
| LFTs |
|
| Renal function tests |
|
| Coagulation studies |
|
| Foetal surveillance, e.g. assessing foetal movement or biophysical profile testing |
|
| Other |
|
Severity classification of gestational hypertension:
- Hypertension: systolic BP ≥ 140/90 mmHg or diastolic BP ≥ 90 mmHg, or both
- Severe hypertension: BP persistently ≥ 160/100 mmHg for a minimum of 4 hours
Complications
- Pre-eclampsia: a severe form of GH, characterised by hypertension, proteinuria and end-organ damage
- Placental abruption: the placenta separates from the uterine wall, causing heavy bleeding and foetal distress
- Intrauterine growth restriction: leads to low birth weight and other complications
- Pre-term delivery: may be necessary if GH is severe or if there are other complications
Management
The management of GH depends on the severity of the condition, and ranges from close monitoring of BP and urine protein levels in mild GH to admission to hospital and antihypertensive treatment in the context of high or persistently elevated BP (summarised in Table 2).
Important considerations
- Lifestyle modifications: the same advice on rest, exercise and work to women with chronic hypertension
- Antihypertensive treatment: Oral labetalol is 1st line (avoid in asthma). Alternatives include:
- Nifedipine if worsening hypertension previously controlled with oral labetalol
- Methyldopa, if labetalol or nifedipine are not suitable; avoid postpartum due to risk of depression, and change to an alternative within 2 days of delivery if started.
- Planned early delivery. Indications include the following:
- Preterm labour or premature rupture of membranes
- Vaginal bleeding
- Abnormal foetal testing
- Intrauterine growth restriction
- Development of pre-eclampsia or eclampsia
- Evidence of end-organ damage (e.g. neurological, hepatic or renal dysfunction)
- Corticosteroids (e.g. betamethasone), if planned early delivery < 37 weeks’ gestation is necessary to promote foetal lung maturation, as indicated
- Magnesium sulphate if planned early delivery < 34 weeks’ gestation, for neuroprotection, as indicated
- Low-dose aspirin (PO 75mg) in subsequent pregnancies to reduce the risk of pregnancy-induced hypertension and pre-eclampsia
Table 7. Management of gestational hypertension
| Management | Mild GH | Severe GH |
|---|---|---|
| Admit to hospital | Not routinely recommended | Admit to hospital |
| BP monitoring | Once or twice per week until BP ≤ 135/85 mmHg | Every 15-30 mins until BP < 160/100 mmHg |
| Urine protein levels | Once or twice per week | Daily |
| Blood tests | FBC, LFTs and renal function at presentation, then weekly PIGF-based testing on 1 occasion if there is suspicion of pre-eclampsia |
|
| Foetal assessment | Foetal heart auscultation at every antenatal appointment | |
| Foetal US at diagnosis – if normal, repeat every 2-4 weeks if indicated | Foetal US at diagnosis – if normal, repeat every 2 weeks if severe HTN persists | |
| CTG only if indicated | CTG at diagnosis; repeat only if indicated | |
| Antihypertensive medication | Not routinely recommended, but may be considered by BP remains elevated (> 140/90 mmHg) despite lifestyle modifications, or if there are concerns regarding maternal/foetal well-being Target BP: ≤ 135/85 mmHg |
1st line options: Labetalol PO/IV, Nifedipine PO, Hydralazine IV Target BP: ≤ 135 /85 mmHg |
| Delivery | Do not offer planned early delivery < 37 weeks’ gestation unless indications for early delivery are met. | Indicated if severe hypertension, end-organ damage or signs of foetal compromise. Timing should balance the risks of prematurity against the risks of continuing the pregnancy |
Postnatal investigation, monitoring and treatment
- Continue monitoring the mother’s BP. Measure BP daily for the first 2 days after birth, at least once between day 3 and day 5, and as clinically indicated afterwards.
- Continue antihypertensive treatment if required. Start treatment if BP ≥ 150/100 mmHg and they were not treated during pregnancy. Reduce treatment dosages if BP falls < 130/80 mmHg
- Follow-up with GP or specialist 6-8 weeks after birth, or 2 weeks after transfer to community care for women who remain on antihypertensive treatment
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