7th June 2025

Aetiology

Loss of function of the gene filaggrin gene function encoding for the protein filaggrin (FLG).
- It is essential in formation of keratohyalin granules which are found in the granular layer of epidermis.
- It is responsible for aggregating keratin filaments which covalently cross link and bind them together to form a condensed skin barrier.
The loss of the gene function results in the disruption in its barrier function as well as reduction/loss of the moisturizing function of the epidermal layer (Xerosis).
Excessive scaling forms as a result of the inability of the skin cells to remain hydrated as they move up through the epidermis.
As a compensatory repair mechanism, hyperkeratosis results.

Complete Guide to Clinical Genetics ST3 Application and Recruitment (2027)

Written by Medibuddy. Last updated: October 2026. Clinical Genetics is

Recruitment paused: NHS England is not running Clinical Radiology ST3+ recru

Written by Medibuddy. Last updated: October 2026. If you’re planning

Our mobile app allows you to access your interview and exam question banks wherever you are.