24th July 2024

Complications of HSCT

There are numerous complications that can occur after HSCT. Complications are considered early if they happen within one year of transplant and late if they occur after this.

Early complications	Late complications
Oral mucositis Diarrhoea Acute GvHD Infection (bacterial, viral, fungal, CMV, atypical) Transplant-associated thrombotic microangiopathy (usually manifest as renal dysfunction) Organ failure (liver, renal, pulmonary)	Chronic GvHD Infections (latent viral, encapsulated bacteria) Cardiovascular disease Pulmonary disease (bronchiolitis obliterans syndrome, restrictive allograft syndrome) Liver disease (GvHD, viral hepatitis reactivation) Hypothyroidism Hypogonadism and infertility Psychological impact

Early complications

Late complications

Oral mucositis

Diarrhoea

Acute GvHD

Infection (bacterial, viral, fungal, CMV, atypical)

Transplant-associated thrombotic microangiopathy (usually manifest as renal dysfunction)

Organ failure (liver, renal, pulmonary)

Chronic GvHD

Infections (latent viral, encapsulated bacteria)

Cardiovascular disease

Pulmonary disease (bronchiolitis obliterans syndrome, restrictive allograft syndrome)