26th February 2025

Clinical features of antiphospholipid syndrome

Antiphospholipid syndrome can cause arterial, venous or microvascular thrombosis. DVT is the most common vascular manifestation, although pulmonary emboli and ischaemic strokes are also common. Cardiac valve abnormalities are seen in 30-50% of patients. Skin manifestations, such as livedo reticularis, can also be associated with antiphospholipid syndrome. Diagnosis is commonly made due to obstetric complications, such as recurrent early miscarriage, fetal loss, intrauterine growth restriction, pre-eclampsia or placental insufficiency.