29th December 2024

Risk factors for neutropenic sepsis

There is an increased risk of neutropenic sepsis in:

• Haematological malignancies
• High-dose/intensive chemotherapy regimes
• Receiving first cycle of chemotherapy or low first-cycle neutrophil nadir < 0.5 x 10⁹/L
• Previous neutropenic fever
• Long duration of, or severe neutropenia
• Performance status > 1
• Older age (> 65 years old )
• Comorbidities including diabetes mellitus, liver disease and renal disease
• Hypoalbuminaemia with (albumin < 35 g/dL)
• Pre-treatment anaemia (pre-treatment haemoglobin < 120 g/L)