10th May 2025

A 22-year-old male attends the Cardiology clinic following an unprovoked PE some months later and an echocardiogram suggestive of a cardiac mass.

A 22-year-old male attends the Cardiology clinic following an unprovoked PE some months later and an echocardiogram suggestive of a cardiac mass. Examination is remarkable for multiple dark-coloured lesions, which the patient reports he has always felt are freckles. He has no overt features of Cushing syndrome, however, he has subacute high cortisol levels.

Which genetic syndrome is associated with multiple and recurrent myxomas of the heart and skin, lentiginosis, and endocrine dysfunction?

Select the SINGLE most appropriate option from the list below. Select ONE option only.