15th July 2024

A 29-year-old woman presents to her GP feeling generally unwell

A 29-year-old woman presents to her GP feeling generally unwell. Physical examination is unremarkable, apart from a blood pressure of 182/100. Investigations undertaken at the acute medical unit show that she is anaemic and thrombocytopenic with evidence of fragments on blood film.  A coagulation panel is normal.  Serum creatinine is elevated at 275 µmol/l and eGFR is 28 ml/min/1.73m2.

What is the most likely diagnosis?

Select the SINGLE most appropriate option from the list below. Select ONE option only.