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26th February 2025
A 32-year-old female is seen in rheumatology clinic.
A 32-year-old female is seen in rheumatology clinic. She has a background of SLE and takes mycophenolate mofetil 500 mg twice daily. She has been feeling generally run down for the past month with increasing joint pains. She has noticed an increased rash on her face, across her nose and cheeks, and a few mouth ulcers.
Her antibody profile at diagnosis is shown below:
| ANA | 1:1280 |
| ENA | Positive |
| Anti-Sm | Positive |
| Anti-Ro | Negative |
| Anti-La | Negative |
| Anti-U1RNP | Negative |
| dsDNA | 52 IU/mL (0-10 IU/mL) |
You think that she is experiencing a flare of her disease and so treat her with oral steroids and increase the dose of the mycophenolate mofetil.
Which antibody can be used to monitor disease activity in SLE?
Select the SINGLE most appropriate option from the list below. Select ONE option only.
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