26th February 2025

A 35-year-old female presents with increasing proximal muscle weakness and shortness of breath over the past few months.

A 35-year-old female presents with increasing proximal muscle weakness and shortness of breath over the past few months. She has violaceous plaques on her knuckles and a purple rash around her eyes with periorbital oedema. Her CK comes back at 1500, and you send off an autoantibody screen.

Given the likely diagnosis, which antibody is most likely to be positive in this condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.