24th June 2026

A 35-year-old female with a history of IVDU and previous endocarditis requiring aortic valve replacement presents generally unwell with fevers, rigors, and a new diastolic murmur.

A 35-year-old female with a history of IVDU and previous endocarditis requiring aortic valve replacement presents generally unwell with fevers, rigors, and a new diastolic murmur. Other than a temperature of 38.6C, her observations are normal. Blood tests show a WCC of 15.7 and a CRP of 142. Blood culture results are positive for methicillin-resistant staphylococcus aureus, which is sensitive to all other antimicrobials. She has no known drug allergies. What is the most appropriate antibiotic to commence her on? 

Select the SINGLE most appropriate option from the list below. Select ONE option only.