23rd May 2025

A 40-year-old female patient has a history of treatment-resistant Cushing’s disease.

A 40-year-old female patient has a history of treatment-resistant Cushing’s disease. Due to this, she underwent transsphenoidal surgery 2 years ago and a bilateral adrenalectomy 4 years ago. The patient also has a history of depression with self-harm and hypothyroidism. She presents to A&E due to blind spots in her vision, headache, irregular periods and tanned skin creases especially notable on old scars.

What is the most likely diagnosis?

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