21st April 2024

A 43-year-old woman presents with fatigue and pruritus. She has a past medical history

A 43-year-old woman presents with fatigue and pruritus. She has a past medical history of hypothyroidism. On examination, she has evidence of xanthelasma around her eyes, clubbing and multiple skin excoriations. Blood tests show bilirubin 8, ALT 60 and ALP 385. Antimitochondrial antibodies are positive.

What is the most appropriate initial treatment for this patient’s condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.