23rd May 2025

A 47-year-old woman presented to your out-patient endocrine clinic with weight loss of 5 stones in the last 2 months, bone pains and neck swelling.

A 47-year-old woman presented to your out-patient endocrine clinic with weight loss of 5 stones in the last 2 months, bone pains and neck swelling. Examination shows hard nodular thyroid mass. CXR shows pulmonary infiltrates. She has been started on Aspirin 300mg 1 week ago after a diagnosis of mini-stroke, where she was found to have right carotid artery stenosis on neck US due to suspected local mass invasion. Which genetic mutation is usually associated with this lesion ?

Select the SINGLE most appropriate option from the list below. Select ONE option only.