5th June 2025

A 56 year-old female presents to her GP with some new salt-and-pepper dyspigmentation on her back.

A 56 year-old female presents to her GP with some new salt-and-pepper dyspigmentation on her back. She tells you her hands have always been cold and can go blue if she doesn’t wear gloves. On further examination, she has subcutaneous calcinosis deposits on her digits as well as some telangiectasias. She is diagnosed with systemic sclerosis and is undergoing further investigations.

Which auto-antibodies are associated with better prognosis in systemic sclerosis?

Select the SINGLE most appropriate option from the list below. Select ONE option only.