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25th July 2024
A 57-year-old female with a background of hereditary spherocytosis presents to A&E
A 57-year-old female with a background of hereditary spherocytosis presents to A&E with worsening fatigue, shortness of breath and pallor. She recalls a mild viral illness within the last 2 weeks but didn’t feel too unwell with it.
Her bloods are as below:
| Hb (115 – 165 g/L) | 72 g/L |
| Neutrophils (1.8 – 7.5 x 10⁹/L) | 0.9 x10⁹/L |
| Platelets (140 – 400 x10⁹/L) | 45 x10⁹/L |
| Bilirubin (<21 μmol/L) | 44 µmol/L |
| LDH (240 – 480 U/L) | 590 u/L |
| Haptoglobin (0.5 – 2.2 g/L) | 0.4 g/L |
| Reticulocytes (0.5 – 2%) | < 0.1% |
What is the most likely cause of this presentation?
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