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15th July 2024
A 57-year-old man with an acute kidney injury secondary to granulomatosis with polyangiitis was treated with oral cyclophosphamide
A 57-year-old man with an acute kidney injury secondary to granulomatosis with polyangiitis was treated with oral cyclophosphamide and tapering oral prednisolone. He achieved good symptomatic relief and his renal function partially recovered. He was admitted to hospital again with a 2-week history of confusion and headache. Investigations were as follows:
Blood tests:
| Serum creatinine | 175 µmol/L (60–110) |
| Random plasma glucose | 5.6 mmol/L |
CSF analysis:
| Opening pressure | 25 mmHg (10-20) |
| Total protein | 2.05 g/L (0.15–0.45) |
| Glucose | 1.3 mmol/L (3.3–4.4) |
| White cell count | 23/µL (<5) |
| Lymphocyte count | 21/µL (<3) |
| Neutrophil count | 2/µL (0) |
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