21st February 2025

A 72-year-old man with a history of asbestos exposure presents with 2 months of worsening breathlessness and chest pain.

A 72-year-old man with a history of asbestos exposure presents with 2 months of worsening breathlessness and chest pain. He has a past medical history of asbestosis and COPD and has a 40-pack-year smoking history. A CT chest demonstrates a large right-sided pleural effusion associated with an area of pleural thickening. A pleural biopsy is performed, which confirms a diagnosis of malignant mesothelioma. 

Which would be the most appropriate chemotherapy regime for this patient? 

Select the SINGLE most appropriate option from the list below. Select ONE option only.