A 74-year-old woman was admitted into the accident and emergency department for a humerus fracture secondary to a fall down a flight of stairs at home.
A 74-year-old woman was admitted into the accident and emergency department for a humerus fracture secondary to a fall down a flight of stairs at home. She reported a preceding 3-month history of leg pain, muscle weakness, fatigue, and weight loss. She has type 2 diabetes mellitus and hypertension, diagnosed 12 years ago. Her medications are Gliclazide 160 mg twice daily, Candesartan 8 mg daily, Aspirin 75 mg daily and Atorvastatin 80 mg daily.
Investigations:
| Serum sodium | 139 mmol/L (137–144) |
| Serum potassium | 5.3 mmol/L (3.5–4.9) |
| Serum urea | 8.2 mmol/L (2.5–7.0) |
| Serum creatinine | 301 μmol/L (60–110) |
| eGFR (MDRD) | 35 mL/min/1.73 m2 (>60) |
| Serum corrected calcium | 2.10 mmol/L (2.20-2.60) |
| Serum phosphate | 1.54 mmol/L (0.80-1.45) |
| Plasma parathyroid hormone | 25.5 (0.9-5.4) |
| DEXA scan T-score | -3.4 |
What is the most suitable first-line therapy?
Select the SINGLE most appropriate option from the list below. Select ONE option only.
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