16th May 2025

A 75-year-old lady is reviewed as an outpatient a number of weeks following discharge where she was treated for gram-negative sepsis.

A 75-year-old lady is reviewed as an outpatient a number of weeks following discharge where she was treated for gram-negative sepsis. During her hospital stay she was treated with gentamicin. She is concerned as her family tells her she is having problems with her hearing. Additionally, her recent blood tests show that her creatinine has risen from 121 micromol/L to 165micromol/L. What is the underlying mechanism that drives nephrotoxicity secondary to gentamicin therapy?

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