16th May 2025

A 75-year-old man is diagnosed with meningitis, and a combination of amoxicillin and gentamicin is started after cerebrospinal fluid culture revealed Enterococcus faecalis susceptible to these antibiotics.

A 75-year-old man is diagnosed with meningitis, and a combination of amoxicillin and gentamicin is started after cerebrospinal fluid culture revealed Enterococcus faecalis susceptible to these antibiotics. Due to prolonged antimicrobial therapy length, it was decided to commence monitoring of gentamicin serum concentrations. Gentamicin is currently being given as a multiple daily dose regimen, how should dose monitoring be performed?

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