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17th May 2025
A 78-year-old woman is due to be discharged from hospital after an elective knee replacement surgery.
A 78-year-old woman is due to be discharged from hospital after an elective knee replacement surgery. She has a history of high blood pressure and antiphospholipid syndrome and is taking Perindopril 5 mg daily and Warfarin 5 mg daily. Warfarin has been stopped preoperatively and low-molecular-weight heparin (LMWH) given during surgery.
Investigations:
| Haemoglobin | 108 g/L (130–180) |
| White cell count | 9.6 × 109/L (4.0–11.0) |
| Platelet count | 326 × 109/L (150–400) |
| INR | 1.1 (<1.4) |
| Serum total bilirubin | 34 µmol/L (1–22) |
| Serum alanine aminotransferase | 29 U/L (5–35) |
| Serum aspartate aminotransferase | 28 U/L (1–31) |
| Serum alkaline phosphatase | 112 U/L (45-105) |
What is the most appropriate management with regards to her anticoagulation therapy?
Select the SINGLE most appropriate option from the list below. Select ONE option only.
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