21st June 2024

A patient is admitted from the emergency department with fever, somnolence and signs of raised intracranial pressure

A patient is admitted from the emergency department with fever, somnolence and signs of raised intracranial pressure.  They undergo investigations which indicate a diagnosis of tuberculous meningitis, the organism ultimately showing sensitivity to all first-line antituberculous agents on phenotypic testing. They return to clinic following discharge at the end of a two-month regimen of rifampicin, isoniazid, pyrazinamide, ethambutol, with adjunctive pyridoxine. A decision is made to stop ethambutol and pyrazinamide at this point. For what additional duration are rifampicin and isoniazid advised to continue?

Select the SINGLE most appropriate option from the list below. Select ONE option only.