16th May 2025

Mr Henry is a 65-year-old man who is currently being managed for a severe diabetic foot infection.

Mr Henry is a 65-year-old man who is currently being managed for a severe diabetic foot infection. Recent wound cultures showed resistant staphylococcus aureus which was sensitive to vancomycin. Microbiology suggested starting vancomycin and aiming for higher target serum levels. One of the nurses came to find you to mention that whilst they were administering the vancomycin the patient began to appear very flushed and red. Upon further questioning the nurse reveals that the ward has been short staffed. When reviewing the patient, he was pruritic with an erythematous rash affecting his face, neck, and upper torso. There was no respiratory or haemodynamic compromise. What complication has Mr Henry developed? 

Select the SINGLE most appropriate option from the list below. Select ONE option only.