13th July 2026

You are attending ward rounds with your consultant and are reviewing Matthew, a 56-year-old admitted with an acute kidney injury secondary to food poisoning.

You are attending ward rounds with your consultant and are reviewing Matthew, a 56-year-old admitted with an acute kidney injury secondary to food poisoning. The consultant asks you which medications may need to be withheld whilst Matthew’s kidney function is impaired. 

Which factor contributes to an increased volume of distribution (Vd) for drugs in renal impairment?

Select the SINGLE most appropriate option from the list below. Select ONE option only.