13th July 2026

You are managing the diabetes medication regimen for Jack, a 55-year-old male with a creatinine clearance of 45 mL/min.

You are managing the diabetes medication regimen for Jack, a 55-year-old male with a creatinine clearance of 45 mL/min. He is currently on metformin therapy. What recommendations would you make for dosing of metformin?

Select the SINGLE most appropriate option from the list below. Select ONE option only.