27th August 2020

In Huntington’s Disease, which repeat sequence on which gene causes Huntington’s Disease?

A 39-year-old male presents to the clinic with a year-long history of progressive involuntary choreiform movements, irritability, and trouble with memory. His father had a similar ‘movement disorder.’ On examination, besides the noticeable chorea, he demonstrates difficulty with rapid alternating movements and has a positive Romberg’s sign. Given the patient’s presentation and family history, you suspect Huntington’s Disease.

Which repeat sequence on which gene is most commonly associated with the development of this condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.