14th September 2020

You are asked to examine a 60-year-old female on the rheumatology ward

You are asked to examine a 60-year-old female on the rheumatology ward. On inspection, she has tight, shiny skin with periungual telangiectasia most noticeable on both hands but also extends to all parts of her body. She mentions that occasionally she develops excruciatingly painful fingers in the cold, of which she was admitted for prostacyclin infusion this episode. 

Which of the following auto-antibodies is most specific for the underlying condition?

Select the SINGLE most appropriate option from the list below. Select ONE option only.