1st April 2022

A 40-year-old female presents to her GP with a two-month history of fatigue, constipation and cold sensations

A 40-year-old female presents to her GP with a two-month history of fatigue, constipation and cold sensations. She has no relevant medical history and was otherwise well before the onset of symptoms. On examination, her observations are: HR 55, BP 110/95, RR 15, Temp 36.5. Additionally, you notice her skin appears coarse and dry, and her face is oedematous. 

Select the SINGLE most likely diagnosis from the list below. Select ONE option only.