27th February 2024

A 45-year-old man attends the antipsychotic patient monitoring service.

DATE	DRUG NAME	DOSE	ROUTE	FREQUENCY	Prescriber’s Signature
10/1/21	BISOPROLOL	10MG	ORAL	ONCE DAILY	DR
10/1/21	CLOZAPINE	50MG	ORAL	ONCE DAILY	DR
10/1/21	HALOPERIDOL	2MG	ORAL	ONCE DAILY	DR
10/1/21	OLANZAPINE	10MG	ORAL	ONCE DAILY	DR
10/1/21	PROPYLTHIOURACIL	100MG	ORAL	TWICE DAILY	DR

A 45-year-old man attends the antipsychotic patient monitoring service. He has known diagnoses of schizophrenia and hyperthyroidism. His symptoms have been well-controlled on treatment however he has been constipated for the past few weeks. The nurse takes a blood test which reveals the following:

Hb 10.4g/dL, WCC 3 x 10ꝰ/L, ANC 1.2 x 10ꝰ/L, platelets 198 x 10ꝰ/L, fasting blood glucose 7.0 mmol/l, Urea 8 mmol/L, creatinine 125 mmol/L

An ECG is obtained which reveals normal sinus rhythm with mild QT prolongation.

His medications are above.

Which of his medications is most likely to cause these side effects?