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27th February 2024
A 63-year-old male is admitted to the HDU following a valve replacement surgery.
A 63-year-old male is admitted to the HDU following a valve replacement surgery. He is on warfarin and his INR is 3. On day 3 post-op he develops a fever and cough. A CXR confirms right-sided lobar pneumonia. He is started on sepsis 6 protocol. Subsequently, his INR is found to be 4.5. He has a past medical history of hypertension, chronic low back pain and psoriasis. His medications are as follows:
| DATE | DRUG NAME | DOSE | ROUTE | FREQUENCY | Prescriber’s Signature |
| 10/1/21 | CLARITHROMYCIN | 500MG | ORAL | TWICE DAILY | DR |
| 10/1/21 | CO-CODAMOL | 8/500MG | ORAL | ONCE DAILY | DR |
| 10/1/21 | INDAPAMIDE | 2.5MG | ORAL | ONCE DAILY | DR |
| 10/1/21 | HYDROCORTISONE | 25MG | ORAL | ONCE DAILY | DR |
| 10/1/21 | PERINDOPRIL | 1.25MG | ORAL | ONCE DAILY | DR |
| 10/1/21 | AMOXICILLIN | 80MG | ORAL | ONCE DAILY | DR |
Select the single most likely drug to be causing the raised INR.
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